Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM375773
Substrate
n/a
Meas. Tech.
Enzyme Inhibition
IC50
<1000±n/a nM
Citation
 Jacques, V; Rusche, JR; Peet, NP; Singh, J Histone deacetylase inhibitors US Patent  US9908899 Publication Date 3/6/2018 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM375773
Synonyms:
US10301323, Compound F7 | US9908899, Compound F7
Type:
Small organic molecule
Emp. Form.:
C25H25ClN4O
Mol. Mass.:
432.945
SMILES:
[#7]-c1ccccc1-[#7]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-c3cccnc3)-[#6]-[#6]-2)c(Cl)c1
Structure:
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