Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM23706
Substrate
BDBM23699
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
104±n/a nM
Citation
Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed] Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Inhibitor
Name:
BDBM23706
Synonyms:
1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 8
Type:
Small organic molecule
Emp. Form.:
C10H6Cl2N2O
Mol. Mass.:
241.073
SMILES:
Clc1ccc(cc1Cl)C(=O)n1cccn1