Target

Ligand

Substrate

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Human Neutrophil Elastase Inhibition Assay

Citation

 Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed]  Article Copy BDB DOI

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Name:

Cathepsin D

Synonyms:

CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor

Type:

Enzyme

Mol. Mass.:

44551.72

Organism:

Homo sapiens (Human)

Description:

Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.

Residue:

412

Sequence:

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

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Name:

BDBM23714

Synonyms:

4-bromo-1-[(3-methylphenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 22

Type:

Small organic molecule

Emp. Form.:

C11H9BrN2O

Mol. Mass.:

265.106

SMILES:

Cc1cccc(c1)C(=O)n1cc(Br)cn1

Structure:

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Similarity to this molecule at least:

Name:

BDBM23737

Synonyms:

(7- Methoxycoumarin- 4- yl)acetyl- Glycyl- L- Lysyl- L- Prolyl- L- Isoleucyl- L- Leucyl- L- Phenylalanyl- L- Phenylalanyl- L- Arginyl- L- Leucyl- Ne- (2,4- Dinitrophenyl)- L- Lysyl- D- Arginine Amide | MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: