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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM376825
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as pim kinase inhibitors US Patent  US9920032 Publication Date 3/20/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM376825
Synonyms:
N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-02R,4R)-4-methoxy-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide | US10450296, Example 156 | US11053215, Example 156 | US9920032, Example 156
Type:
Small organic molecule
Emp. Form.:
C28H34FN5O2
Mol. Mass.:
491.6003
SMILES:
CO[C@@H]1C[C@@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r|
Structure:
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