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Target
Orexin receptor type 2
Ligand
BDBM376849
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
51.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Methyl oxazole orexin receptor antagonists US Patent  US9920038 Publication Date 3/20/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM376849
Synonyms:
(R)-(2-(1H-pyrazol-1- yl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone | US9920038, 10
Type:
Small organic molecule
Emp. Form.:
C23H28N4O3
Mol. Mass.:
408.4934
SMILES:
Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2cccn2)nc1C(C)(C)O |r|
Structure:
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