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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM376850
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
>10000±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Methyl oxazole orexin receptor antagonists US Patent  US9920038 Publication Date 3/20/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM376850
Synonyms:
(R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2-trifluoroethyl)pyridin-3- yl)methanone | US9920038, 11
Type:
Small organic molecule
Emp. Form.:
C21H26F3N3O3
Mol. Mass.:
425.4446
SMILES:
Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2CC(F)(F)F)nc1C(C)(C)O |r|
Structure:
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