Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM376857
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
1687±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Methyl oxazole orexin receptor antagonists US Patent  US9920038 Publication Date 3/20/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM376857
Synonyms:
(R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2-trifluoroethyl)phenyl)- methanone | US9920038, 18
Type:
Small organic molecule
Emp. Form.:
C22H27F3N2O3
Mol. Mass.:
424.4566
SMILES:
Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2CC(F)(F)F)nc1C(C)(C)O |r|
Structure:
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