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Target
Orexin receptor type 2
Ligand
BDBM376869
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
46.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Methyl oxazole orexin receptor antagonists US Patent  US9920038 Publication Date 3/20/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM376869
Synonyms:
(R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(5- methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)methanone | US9920038, 30
Type:
Small organic molecule
Emp. Form.:
C23H29N5O3
Mol. Mass.:
423.5081
SMILES:
Cc1oc(C[C@H]2CCCCN2C(=O)c2cc(C)ccc2-n2nccn2)nc1C(C)(C)O |r|
Structure:
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