Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM261615
Substrate
n/a
Meas. Tech.
AT2 Receptor Binding Assay
IC50
155±n/a nM
Citation
 McCarthy, TD; Naylor, A Heterocyclic compounds and methods for their use US Patent  US9708275 Publication Date 7/18/2017 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM261615
Synonyms:
(S)-1-(2,2-diphenylacetyl)-4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine-2-carboxylic acid | US9708275, Compound 10 | US9708275, Compound 7
Type:
Small organic molecule
Emp. Form.:
C28H30N2O3
Mol. Mass.:
442.5494
SMILES:
OC(=O)[C@@H]1CN(CCCc2ccccc2)CCN1C(=O)C(c1ccccc1)c1ccccc1 |r|
Structure:
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