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Target
Alpha-glucosidase MAL32
Ligand
BDBM23851
Substrate
BDBM23837
Meas. Tech.
alpha-Glucosidase Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
5100±n/a nM
Citation
Dodo, K; Aoyama, A; Noguchi-Yachide, T; Makishima, M; Miyachi, H; Hashimoto, Y Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem 16:4272-85 (2008) [PubMed] Article
More Info.:
Target
Name:
Alpha-glucosidase MAL32
Synonyms:
Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase)
Type:
Hydrolase
Mol. Mass.:
68132.36
Organism:
Saccharomyces cerevisiae
Description:
Purchased from Wako Fine Chemicals Co. Ltd.
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
Inhibitor
Name:
BDBM23851
Synonyms:
14-oxapentacyclo[20.2.2.2^{10,13}.1^{15,19}.0^{2,7}]nonacosa-1(25),2(7),3,5,10,12,15,17,19(27),22(26),23,28-dodecaene-5,24-diol | Riccardin C derivative, 20d
Type:
Small organic molecule
Emp. Form.:
C28H24O3
Mol. Mass.:
408.4884
SMILES:
Oc1ccc-2c(CCc3ccc(Oc4cccc(CCc5ccc-2c(O)c5)c4)cc3)c1
Substrate
Name:
BDBM23837
Synonyms:
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol | 4-nitrophenyl alpha-glucoside | p-NPG | p-Nitrophenyl alpha-D-glucopyranoside | pNPG
Type:
Chromogenic substrate
Emp. Form.:
C12H15NO8
Mol. Mass.:
301.2494
SMILES:
OC[C@H]1O[C@H](Oc2ccc(cc2)[N+]([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O