Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM377185
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
>40.0±n/a nM
Citation
 Xue, CFeng, HLi, YZhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US10265307 Publication Date 4/23/2019 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM377185
Synonyms:
N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | US10265307, Example 35 | US10517858, Example 35 | US10828290, Example 35 | US11229631, Example 35
Type:
Small organic molecule
Emp. Form.:
C21H19F2N7OS
Mol. Mass.:
455.484
SMILES:
N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2[nH]ncc12 |r|
Structure:
Search PDB for entries with ligand similarity: