Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM377218
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
<100±n/a nM
Citation
 Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US10265307 Publication Date 4/23/2019 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM377218
Synonyms:
US10265307, Example 56-2 | US10517858, Example 56 (Diastereoisomer 2) | US10828290, Example 56 (Diastereoisomer 2) | US11229631, Example 56 Diastereoisomer 2
Type:
Small organic molecule
Emp. Form.:
C27H28F3N5O3
Mol. Mass.:
527.5381
SMILES:
COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1C[C@H](C)C[C@H](N)C1 |r,wU:35.39,32.36,wD:24.26,(7.19,4.83,;5.85,5.6,;4.52,4.83,;3.19,5.6,;1.85,4.83,;1.85,3.29,;.52,2.52,;3.19,2.52,;4.52,3.29,;5.85,2.52,;3.19,.98,;1.85,.21,;1.85,-1.33,;3.19,-2.1,;4.52,-1.33,;4.52,.21,;5.85,.98,;.52,-2.1,;.52,-3.64,;-.82,-1.33,;-2.15,-2.1,;-2.15,-3.64,;-3.48,-4.41,;-4.82,-3.64,;-6.28,-4.11,;-6.68,-5.6,;-7.19,-2.87,;-6.28,-1.62,;-4.82,-2.1,;-3.48,-1.33,;-3.48,.21,;-2.15,.98,;-2.15,2.52,;-.82,3.29,;-3.48,3.29,;-4.82,2.52,;-6.15,3.29,;-4.82,.98,)|
Structure:
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