Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM377220
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
<100±n/a nM
Citation
 Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US10265307 Publication Date 4/23/2019 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM377220
Synonyms:
N-{4-[(3S)-3-Aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxamide | US10265307, Example 58-1
Type:
Small organic molecule
Emp. Form.:
C26H26F3N5O2S
Mol. Mass.:
529.577
SMILES:
CSc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2C(O)CCc2c1N1CCC[C@H](N)C1 |r,wU:34.38,(5.19,6.76,;3.85,5.99,;3.85,4.45,;2.52,3.68,;2.52,2.14,;1.18,1.37,;3.85,1.37,;5.19,2.14,;6.52,1.37,;5.19,3.68,;3.85,-.17,;2.52,-.94,;2.52,-2.48,;3.85,-3.25,;5.19,-2.48,;5.19,-.94,;6.52,-.17,;1.18,-3.25,;1.18,-4.79,;-.15,-2.48,;-1.48,-3.25,;-1.48,-4.79,;-2.82,-5.56,;-4.15,-4.79,;-5.61,-5.27,;-6.01,-6.76,;-6.52,-4.02,;-5.61,-2.78,;-4.15,-3.25,;-2.82,-2.48,;-2.82,-.94,;-1.48,-.17,;-1.48,1.37,;-2.82,2.14,;-4.15,1.37,;-5.48,2.14,;-4.15,-.17,)|
Structure:
Search PDB for entries with ligand similarity: