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Target
N-formyl peptide receptor 2
Ligand
BDBM377297
Substrate
n/a
Meas. Tech.
Measuring Agonistic Activity of Compounds in hFPR1-Gα15-CHO and hFPR2-Aq-CHO Cell
EC50
<1±n/a nM
Citation
 Jakob, F; Nordhoff, S; Rider, D; Wagener, M; Bahrenberg, G; Dunkern, T 6-membered cyclic amines or lactames substituted with urea and phenyl US Patent  US10265310 Publication Date 4/23/2019 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM377297
Synonyms:
US10265310, Example 50 | trans-ent2-1-(4-chlorophenyl)-3-(4-(2,6-difluoro-4-methoxyphenyl)-6-oxopiperidin-3-yl)urea
Type:
Small organic molecule
Emp. Form.:
C19H18ClF2N3O3
Mol. Mass.:
409.814
SMILES:
COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Structure:
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