Target
Tyrosine-protein kinase BTK
Ligand
BDBM377362
Substrate
n/a
Meas. Tech.
Human Recombinant Btk Enzyme Assay
IC50
0.120±n/a nM
Citation
 Ahmad, SBatt, DGLiu, QMacor, JETino, JAWatterson, SHNair, SKMaishal, TK Carbazole derivatives US Patent  US10266491 Publication Date 4/23/2019 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM377362
Synonyms:
US10266491, Example 30 | US10676434, Example 30 | US11053197, Example 30
Type:
Small organic molecule
Emp. Form.:
C26H26FN3O4S
Mol. Mass.:
495.566
SMILES:
CN(c1cccc(c1C)-c1c(F)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O)S(=O)(=O)C=C |(3.75,-5.78,;3.75,-4.23,;2.42,-3.47,;1.08,-4.23,;-.25,-3.47,;-.25,-1.93,;1.08,-1.15,;2.42,-1.93,;3.75,-1.15,;1.08,.38,;2.42,1.15,;3.75,.39,;2.42,2.69,;1.08,3.47,;1.08,5,;2.42,5.78,;-.25,5.78,;-.25,2.69,;-1.71,3.17,;-2.62,1.93,;-4.15,1.76,;-4.78,.36,;-3.87,-.89,;-2.34,-.73,;-1.71,.68,;-.25,1.15,;-6.26,-.04,;-6.66,1.45,;-7.75,.36,;-6.66,-1.53,;5.09,-3.47,;4.32,-2.13,;5.86,-2.13,;6.42,-4.23,;7.75,-3.47,)|
Structure:
Search PDB for entries with ligand similarity: