Reaction Details Report a problem with these data
Target
Bacterial leucyl aminopeptidase
Ligand
BDBM23982
Substrate
BDBM23972
Meas. Tech.
Enzyme Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
500000±n/a nM
Citation
 Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed]  Article 
Target
Name:
Bacterial leucyl aminopeptidase
Synonyms:
AMPX_VIBPR | Bacterial leucyl aminopeptidase precursor
Type:
PROTEIN
Mol. Mass.:
54213.72
Organism:
Vibrio proteolyticus
Description:
ChEMBL_1507540
Residue:
504
Sequence:
MKYTKTLLAMVLSATFCQAYAEDKVWISIGADANQTVMKSGAESILPNSVASSGQVWVGQVDVAQLAELSHNMHEEHNRCGGYMVHPSAQSAMAASAMPTTLASFVMPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSNFTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATGDTPTPGNQLEDGVPVTDLSGSRGSNVWYTFELETQKNLQITTSGGYGDLDLYVKFGSKASKQNWDCRPYLSGNNEVCTFNNASPGTYSVMLTGYSNYSGASLKASTF
  
Inhibitor
Name:
BDBM23982
Synonyms:
1-(3-amino-1,2,3,4-tetrahydronaphthalen-2-yl)ethan-1-one hydrochloride | tetrahydronaphthalene-2-ethanone, 3b
Type:
Small organic molecule
Emp. Form.:
C12H15NO
Mol. Mass.:
189.2536
SMILES:
CC(=O)C1Cc2ccccc2CC1N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23972
Synonyms:
(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide | L-Leucine-p-nitroanilide | L-Leucine-para-nitroanilide
Type:
n/a
Emp. Form.:
C12H17N3O3
Mol. Mass.:
251.2817
SMILES:
CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: