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Target
Leukotriene A-4 hydrolase
Ligand
BDBM24224
Substrate
BDBM24200
Meas. Tech.
Epoxide Hydrolase Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
8±5 nM
Citation
 Grice, CA; Tays, KL; Savall, BM; Wei, J; Butler, CR; Axe, FU; Bembenek, SD; Fourie, AM; Dunford, PJ; Lundeen, K; Coles, F; Xue, X; Riley, JP; Williams, KN; Karlsson, L; Edwards, JP Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem 51:4150-69 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM24224
Synonyms:
1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}piperidin-4-ol | Benzthiazole compound, 27e
Type:
Small organic molecule
Emp. Form.:
C20H22N2O2S
Mol. Mass.:
354.466
SMILES:
OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Structure:
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Substrate
Name:
BDBM24200
Synonyms:
4-[(2S,3S)-3-[(1E,3E,5Z,8Z)-tetradeca-1,3,5,8-tetraen-1-yl]oxiran-2-yl]butanoic acid | 4-{(2S,3S)-3-[(1E,3E,5Z,8Z)-tetradeca-1,3,5,8-tetraen-1-yl]oxiran-2-yl}butanoic acid | CHEMBL69439 | LTA4 | Leukotriene A4
Type:
Fatty Acids, Unsaturated
Emp. Form.:
C20H30O3
Mol. Mass.:
318.4504
SMILES:
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O |r|
Structure:
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