Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM24268
Substrate
BDBM23991
Meas. Tech.
Peptidase Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
730±n/a nM
Km
1000000±n/a nM
Citation
Kirkland, TA; Adler, M; Bauman, JG; Chen, M; Haeggström, JZ; King, B; Kochanny, MJ; Liang, AM; Mendoza, L; Phillips, GB; Thunnissen, M; Trinh, L; Whitlow, M; Ye, B; Ye, H; Parkinson, J; Guilford, WJ Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem 16:4963-83 (2008) [PubMed] Article
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
Inhibitor
Name:
BDBM24268
Synonyms:
Modified amino acid analog, 8c | methyl (2S)-2-amino-4-{[3-(benzyloxy)phenyl]carbamoyl}butanoate
Type:
Small organic molecule
Emp. Form.:
C19H22N2O4
Mol. Mass.:
342.389
SMILES:
COC(=O)[C@@H](N)CCC(=O)Nc1cccc(OCc2ccccc2)c1 |r|