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Target
Leukotriene A-4 hydrolase
Ligand
BDBM24281
Substrate
BDBM23991
Meas. Tech.
Peptidase Assay
IC50
150±n/a nM
Citation
 Kirkland, TA; Adler, M; Bauman, JG; Chen, M; Haeggström, JZ; King, B; Kochanny, MJ; Liang, AM; Mendoza, L; Phillips, GB; Thunnissen, M; Trinh, L; Whitlow, M; Ye, B; Ye, H; Parkinson, J; Guilford, WJ Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem 16:4963-83 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM24281
Synonyms:
(2S)-2-amino-N-[4-(3-methylphenoxy)phenyl]pentanediamide | Modified amino acid analog, 9d
Type:
Small organic molecule
Emp. Form.:
C18H21N3O3
Mol. Mass.:
327.3776
SMILES:
Cc1cccc(Oc2ccc(NC(=O)CC[C@H](N)C(N)=O)cc2)c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23991
Synonyms:
(2S)-2-amino-N-(4-nitrophenyl)propanamide | Ala-4-nitroanilide | Alanine para-nitroanilide | L-Alanine-4-nitroanilide
Type:
n/a
Emp. Form.:
C9H11N3O3
Mol. Mass.:
209.2019
SMILES:
C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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