| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Ligand | BDBM380444 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | <300±n/a nM |
|---|
| Citation |  Li, Y; Zhuo, J; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent US9926301 Publication Date 3/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Name: | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Synonyms: | JAK1 (aa 837-1142) | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35230.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23458[837-1142] |
|---|
| Residue: | 306 |
|---|
| Sequence: | FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
|
|
|
|---|
| BDBM380444 |
|---|
| Name | BDBM380444 |
|---|
| Synonyms: | 5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-isopropylpyrazine-2-carboxamide | US10435392, Example 8 | US9926301, Example 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25N9O |
|---|
| Mol. Mass. | 419.4829 |
|---|
| SMILES | CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C |
|---|
| Structure |  |
|---|
| n/a |
|---|
Search and Browse
