| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [837-1142] |
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| Ligand | BDBM380448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | 650±n/a nM |
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| Citation |  Li, Y; Zhuo, J; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent US9926301 Publication Date 3/27/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [837-1142] |
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| Name: | Tyrosine-protein kinase JAK1 [837-1142] |
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| Synonyms: | JAK1 (aa 837-1142) | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142) |
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| Type: | n/a |
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| Mol. Mass.: | 35230.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[837-1142] |
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| Residue: | 306 |
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| Sequence: | FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
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| BDBM380448 |
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| Name | BDBM380448 |
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| Synonyms: | 4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,1′H-4,4′-bipyrazol-1-yl]azetidin-1-yl}-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide trifluoroacetate | US10435392, Example 12 | US9926301, Example 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F5N7O2 |
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| Mol. Mass. | 509.4319 |
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| SMILES | C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1CO)C(F)(F)F |r| |
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| Structure |  |
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| n/a |
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