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TargetJAK1 (aa 837-1142)
LigandBDBM380449
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50<300±n/a nM
Citation Li, YZhuo, JMei, S Bipyrazole derivatives as JAK inhibitors US Patent US9926301 Publication Date 3/27/2018
More Info.:Get all data from this article,  Assay Method
 
JAK1 (aa 837-1142)
Name:JAK1 (aa 837-1142)
Synonyms:Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:n/a
Mol. Mass.:35230.04
Organism:Homo sapiens (Human)
Description:n/a
Residue:306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM380449
n/a
NameBDBM380449
Synonyms:4-{3-(Cyanomethyl)-3-[3-(hydroxymethyl)-3′-methyl-1H,1′H-4,4′-bipyrazol-1-yl]azetidin-1-yl}-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide | US10435392, Example 13 | US9926301, Example 13
TypeSmall organic molecule
Emp. Form.C23H22F5N7O2
Mol. Mass.523.4585
SMILESC[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(c(CO)n1)-c1c[nH]nc1C)C(F)(F)F |r|
Structure
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