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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM261772
Substrate
n/a
Meas. Tech.
Test for Antagonism
Temperature
298.15±n/a K
IC50
143±n/a nM
Comments
extracted
Citation
 Peters, O; Bräuer, N; Blume, T; Ter Laak, A; Zorn, L; Nagel, J; Kaulfuss, S; Langer, G; Kuhnke, J Benzimidazole derivatives as EP4 antagonists US Patent  US9708311 Publication Date 7/18/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM261772
Synonyms:
US9708311, 23 | [1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)-1H-benzimidazol-5-yl](3-hydroxyazetidin-1-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C29H28N4O2
Mol. Mass.:
464.5582
SMILES:
CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)N1CC(O)C1
Structure:
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