Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM261857
Substrate
n/a
Meas. Tech.
Test for Antagonism
Temperature
298.15±n/a K
IC50
433±n/a nM
Comments
extracted
Citation
 Peters, OBräuer, NBlume, TTer Laak, AZorn, LNagel, JKaulfuss, SLanger, GKuhnke, J Benzimidazole derivatives as EP4 antagonists US Patent  US9708311 Publication Date 7/18/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM261857
Synonyms:
1-(Cyclopropylmethyl)-2-(9-ethyl-9H-pyrido[2,3-b]indol-3-yl)-4-methyl-1H-benzimidazole-5-carboxylic acid | US9708311, 107
Type:
Small organic molecule
Emp. Form.:
C26H24N4O2
Mol. Mass.:
424.4944
SMILES:
CCn1c2ccccc2c2cc(cnc12)-c1nc2c(C)c(ccc2n1CC1CC1)C(O)=O
Structure:
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