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Target
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Ligand
BDBM24533
Substrate
BDBM13432
Meas. Tech.
Phosphatase Activity Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
800±200 nM
Citation
 Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51:4948-56 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein-Tyrosine Phosphatase SHP-2 | SH-PTP3 | SHPTP2 | Shp2
Type:
Protein phosphatase
Mol. Mass.:
44924.47
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion SHP-2 (205-593).
Residue:
389
Sequence:
TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQ
  
Inhibitor
Name:
BDBM24533
Synonyms:
(3Z)-3-[2-(2-carboxyphenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid | Oxindole scaffold, 14a
Type:
Small organic molecule
Emp. Form.:
C16H11N3O5
Mol. Mass.:
325.2756
SMILES:
OC(=O)c1ccc2NC(=O)C(=NNc3ccccc3C(O)=O)c2c1 |w:11.11|
Structure:
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Substrate
Name:
BDBM13432
Synonyms:
6,8-difluoro-4-methylumbelliferyl phosphate | DiFMUP | [(6,8-difluoro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C10H7F2O6P
Mol. Mass.:
292.1295
SMILES:
Cc1cc(=O)oc2c(F)c(OP(O)(O)=O)c(F)cc12
Structure:
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