Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Ligand
BDBM24535
Substrate
BDBM13432
Meas. Tech.
Phosphatase Activity Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
19400±1800 nM
Citation
Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51:4948-56 (2008) [PubMed] Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Synonyms:
HCP | Hematopoietic cell protein-tyrosine phosphatase | PTN6_HUMAN | PTP-1C | PTP1C | PTPN6 | Protein-Tyrosine Phosphatase SHP-1 | Protein-tyrosine phosphatase 1C | SH-PTP1 | Tyrosine-protein phosphatase non-receptor type 6
Type:
Protein phosphatase
Mol. Mass.:
44886.26
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion SHP-1 (205-595).
Residue:
391
Sequence:
AFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Inhibitor
Name:
BDBM24535
Synonyms:
3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]carbamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 16
Type:
Small organic molecule
Emp. Form.:
C23H17ClN4O4
Mol. Mass.:
448.858
SMILES:
OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)C(=O)NCc2ccc(Cl)cc2)c1 |w:9.8|