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TargetG-protein coupled receptor 6
LigandBDBM190927
Substrate/Competitorn/a
Meas. Tech.cAMP assay A.2
IC50 85000±n/a nM
Citation Brown, JWHitchcock, SHopkins, MKikuchi, SMonenschein, HReichard, HSchleicher, KSun, HMacklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent US9708313 Publication Date 7/18/2017
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM190927
NameBDBM190927
Synonyms:US10077266, Example 38 | US9181249, 38 | US9708313, 38
TypeSmall organic molecule
Emp. Form.C25H29F4N5O2
Mol. Mass.507.5237
SMILESCC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1
Structure
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