Reaction Details Report a problem with these data
Target
G-protein coupled receptor 6
Ligand
BDBM191015
Substrate
n/a
Meas. Tech.
cAMP assay A.1
IC50
55000±n/a nM
Citation
 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent  US9708313 Publication Date 7/18/2017 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM191015
Synonyms:
US10077266, Example 128 | US9181249, 128 | US9708313, 128
Type:
Small organic molecule
Emp. Form.:
C24H29F2N5O2
Mol. Mass.:
457.5162
SMILES:
CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Structure:
Search PDB for entries with ligand similarity: