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Target
G-protein coupled receptor 6
Ligand
BDBM191028
Substrate
n/a
Meas. Tech.
cAMP assay A.1
IC50
122000±n/a nM
Citation
 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent  US9708313 Publication Date 7/18/2017 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM191028
Synonyms:
US10077266, Example 140 | US9181249, 140 | US9708313, 140
Type:
Small organic molecule
Emp. Form.:
C24H30F2N6O2
Mol. Mass.:
472.5308
SMILES:
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3C[C@H](O)C3)nc2C1 |r,wU:26.27,28.30,(9.34,-.07,;8,-.84,;8,-2.38,;6.67,-.07,;6.67,1.47,;5.33,2.24,;4,1.47,;2.67,2.24,;1.33,1.47,;,2.24,;-1.33,1.47,;-2.67,2.24,;-2.67,3.78,;-4,4.55,;-5.33,3.78,;-5.33,2.24,;-6.67,1.47,;-8,2.24,;-9.34,1.47,;-8,3.78,;-6.67,4.55,;-6.67,6.09,;-1.33,4.55,;,3.78,;1.33,-.07,;,-.84,;,-2.38,;-1.09,-3.47,;,-4.55,;,-6.09,;1.09,-3.47,;2.67,-.84,;4,-.07,;5.33,-.84,)|
Structure:
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