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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM380552
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
113±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9926330 Publication Date 3/27/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM380552
Synonyms:
4-{trans-4-[(6- methylquinazolin- 4- yl)amino]cyclo- hexyl}piperazin-2- one | US9926330, 2-5
Type:
Small organic molecule
Emp. Form.:
C19H25N5O
Mol. Mass.:
339.4347
SMILES:
Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCNC(=O)C3)c2c1 |r,wU:10.9,wD:13.16,(-1.93,7.34,;-2.7,6,;-4.23,6,;-5.01,4.67,;-4.23,3.33,;-5,2,;-4.23,.67,;-2.69,.67,;-1.92,2,;-.38,2,;.38,.67,;1.93,.67,;2.7,-.67,;1.93,-2,;.38,-2,;-.38,-.67,;2.69,-3.33,;4.23,-3.33,;5.01,-4.67,;4.23,-6,;2.69,-6,;1.93,-7.34,;1.92,-4.67,;-2.69,3.33,;-1.93,4.67,)|
Structure:
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