Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM380569
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
67.0±n/a nM
Citation
 Altman, MDBrubaker, JDChilders, MLDonofrio, AFischmann, TGibeau, CRKattar, SDLesburg, CALim, JMacLean, JKMansoor, UFNorthrup, ABSanders, JMSmith, GF Inhibitors of IRAK4 activity US Patent  US9926330 Publication Date 3/27/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM380569
Synonyms:
US9926330, 2-22 | trans-N-(6- methylquinazolin-4-yl)-N'- [(1S)-3,3,3-trifluoro-1- methylpropyl]cyclohexane- 1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C19H25F3N4
Mol. Mass.:
366.4238
SMILES:
CC(CC(F)(F)F)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12 |r,wU:8.7,wD:11.14,(3.47,-2.67,;2.69,-4,;3.47,-5.33,;5,-5.33,;5.78,-6.67,;5.78,-4,;6.54,-5.33,;1.15,-4,;.39,-2.67,;-1.15,-2.67,;-1.92,-1.33,;-1.15,,;.39,,;1.16,-1.33,;-1.92,1.33,;-3.46,1.33,;-4.23,,;-5.77,,;-6.54,1.33,;-5.77,2.67,;-6.54,4,;-5.77,5.33,;-4.23,5.33,;-3.46,6.67,;-3.46,4,;-4.23,2.67,)|
Structure:
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