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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM380589
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
10.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9926330 Publication Date 3/27/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM380589
Synonyms:
3-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino]- quinazolin-6-yl}propan- 1-ol | US9926330, 5-2
Type:
Small organic molecule
Emp. Form.:
C21H30N4O2
Mol. Mass.:
370.4885
SMILES:
OCCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:13.12,wD:16.19,(1.93,7.34,;.38,7.34,;-.38,6,;-1.93,6,;-2.7,4.67,;-4.23,4.67,;-5.01,3.33,;-4.23,2,;-5,.67,;-4.23,-.67,;-2.69,-.67,;-1.92,.67,;-.38,.67,;.38,-.67,;1.93,-.67,;2.7,-2,;1.93,-3.33,;.38,-3.33,;-.38,-2,;2.69,-4.67,;1.92,-6,;2.69,-7.34,;4.23,-7.34,;5.01,-6,;4.23,-4.67,;-2.69,2,;-1.93,3.33,)|
Structure:
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