Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM24663
Substrate
BDBM21974
Meas. Tech.
Enzyme Inhibition and Ki Determination
pH
6.5±n/a
Temperature
310.15±n/a K
Ki
8900±n/a nM
IC50
4800±n/a nM
Citation
Kumar, S; Jaller, D; Patel, B; LaLonde, JM; DuHadaway, JB; Malachowski, WP; Prendergast, GC; Muller, AJ Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem 51:4968-77 (2008) [PubMed] Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Inhibitor
Name:
BDBM24663
Synonyms:
2-(1H-imidazol-4-yl)phenol | 2-(1H-imidazol-4-yl)phenol, 1
Type:
Small organic molecule
Emp. Form.:
C9H8N2O
Mol. Mass.:
160.1726
SMILES:
Oc1ccccc1-c1c[nH]cn1