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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM291182
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Sun, Y; Feng, H; Li, Y; Mei, S; Pan, J; Wang, A; Ye, H; Zhang, K Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors US Patent  US9890162 Publication Date 2/13/2018 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM291182
Synonyms:
N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluoro-4-methoxyphenyl)-1,5-naphthyridine-2-carboxamide | US9580418, Example 4 | US9890162, Example 4
Type:
Small organic molecule
Emp. Form.:
C27H26F2N6O2
Mol. Mass.:
504.5311
SMILES:
COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1 |r|
Structure:
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