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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM291219
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Sun, Y; Feng, H; Li, Y; Mei, S; Pan, J; Wang, A; Ye, H; Zhang, K Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors US Patent  US9890162 Publication Date 2/13/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM291219
Synonyms:
N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide | US9580418, Example 39 | US9890162, Example 39
Type:
Small organic molecule
Emp. Form.:
C26H28N8O2
Mol. Mass.:
484.5529
SMILES:
Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1 |r|
Structure:
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