Target
Ribosomal protein S6 kinase alpha-5
Ligand
BDBM24995
Substrate
Fluorescent-labeled Crosstide
Meas. Tech.
In Vitro Kinase Inhibition Assay
IC50
13±n/a nM
Citation
 Heerding, DARhodes, NLeber, JDClark, TJKeenan, RMLafrance, LVLi, MSafonov, IGTakata, DTVenslavsky, JWYamashita, DSChoudhry, AECopeland, RALai, ZSchaber, MDTummino, PJStrum, SLWood, ERDuckett, DREberwein, DKnick, VBLansing, TJMcConnell, RTZhang, SMinthorn, EAConcha, NOWarren, GLKumar, R Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem 51:5663-79 (2008) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-5
Synonyms:
90 kDa ribosomal protein S6 kinase 5 | KS6A5_HUMAN | MSK1 | Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) | Nuclear mitogen- and stress-activated protein kinase 1 | Nuclear mitogen- and stress-activated protein kinase 1 (MSK1) | RPS6KA5 | RPS6KA5(Kin.Dom.2 - C-terminal) | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha 5 | Ribosomal protein S6 kinase alpha-5
Type:
Serine/threonine-protein kinase
Mol. Mass.:
89874.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
802
Sequence:
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
  
Inhibitor
Name:
BDBM24995
Synonyms:
2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperidin-4-yl)-1H-imidazo[4,5-c]pyridine-7-carboxamide | oxadiazole-containing compound, 8
Type:
Small organic molecule
Emp. Form.:
C16H20N8O2
Mol. Mass.:
356.3824
SMILES:
CCn1c(nc2cncc(C(=O)NC3CCNCC3)c12)-c1nonc1N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorescent-labeled Crosstide
Synonyms:
5(6)-Carboxytetramethylrhodamine-labeled peptide | TAMRA-labeled peptide
Type:
Fluorescent dye labeled peptide
Mol. Mass.:
1165.24
Organism:
n/a
Description:
n/a
Residue:
11
Sequence:
GRPRTSSFAEG