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TargetCGRP type 1 receptor
LigandBDBM362044
Substrate/Competitorn/a
Meas. Tech.NATIVE RECEPTOR BINDING ASSA
Ki 0.015±n/a nM
Citation Bell, IMFraley, MEGallicchio, SNGinetti, AMitchell, HJPaone, DVStaas, DDWang, CZartman, CB Piperidinone carboxamide azaindane CGRP receptor antagonists US Patent US10272077 Publication Date 4/30/2019
More Info.:Get all data from this article,  Assay Method
 
CGRP type 1 receptor
Name:CGRP type 1 receptor
Synonyms:CGRP type 1 receptor mRNA | Human CL receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:52980.45
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM362044
NameBDBM362044
Synonyms:US10272077, Example 4 | US9833448, Example 4
TypeSmall organic molecule
Emp. Form.C29H23F6N5O3
Mol. Mass.603.515
SMILESC[C@@H]1[C@@H](C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N1CC(F)(F)F)c1c(F)ccc(F)c1F |r|
Structure
n/a