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Target
G-protein coupled receptor 6
Ligand
BDBM382113
Substrate
n/a
Meas. Tech.
A.1 Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50
30200±n/a nM
Citation
 Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent  US10273225 Publication Date 4/30/2019 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM382113
Synonyms:
(S)-6-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide | US10000468, Example 22 | US10273225, Example 22
Type:
Small organic molecule
Emp. Form.:
C21H26F3N5O
Mol. Mass.:
421.4592
SMILES:
CNC(=O)c1cnc(NC(C)C)c(n1)N1CCC(CC1)[C@H](F)c1ccc(F)cc1F |r|
Structure:
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