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TargetG-protein coupled receptor 6
LigandBDBM382114
Substrate/Competitorn/a
Meas. Tech.A.1 Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50 172000±n/a nM
Citation Adams, MEBrown, JWHitchcock, SHopkins, MKikuchi, SLam, BMonenschein, HReichard, HSun, H Pyrazines as modulators of GPR6 US Patent US10273225 Publication Date 4/30/2019
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM382114
NameBDBM382114
Synonyms:6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-(2-(dimethylamino)-ethyl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide | US10000468, Example 23 | US10273225, Example 23
TypeSmall organic molecule
Emp. Form.C24H34F2N6O2
Mol. Mass.476.5626
SMILESCC(C)Nc1ncc(nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)CCN(C)C
Structure
n/a