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Target
G-protein coupled receptor 6
Ligand
BDBM382120
Substrate
n/a
Meas. Tech.
A.1 Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50
184000±n/a nM
Citation
 Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent  US10273225 Publication Date 4/30/2019 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM382120
Synonyms:
5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-6-(cyclopropylamino)pyrazine-2-carbonitrile | US10000468, Example 29 | US10273225, Example 29
Type:
Small organic molecule
Emp. Form.:
C19H19ClFN5O
Mol. Mass.:
387.838
SMILES:
Fc1cc(Cl)ccc1OC1CCN(CC1)c1ncc(nc1NC1CC1)C#N
Structure:
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