Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM138377
Substrate
n/a
Meas. Tech.
The FP assay
IC50
5604±n/a nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138377
Synonyms:
US10278929, Compound 26 | US11337935, Compound 26 | US8877795, 26
Type:
Small organic molecule
Emp. Form.:
C17H10F3N3O2S
Mol. Mass.:
377.34
SMILES:
Oc1nc(O)c2sc3nc(cc(Cc4ccccc4)c3c2n1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: