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Target
Transthyretin
Ligand
BDBM383209
Substrate
n/a
Meas. Tech.
Determination of Binding Constants of HITS to TTR
Kd
820±129.7 nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM383209
Synonyms:
US10278929, Compound 5 | US11337935, Compound 5
Type:
Small organic molecule
Emp. Form.:
C40H33Cl2N3O10S
Mol. Mass.:
818.675
SMILES:
OC(=O)c1ccccc1Nc1cc(Cl)c(OCCOCCOCCNC(=S)Nc2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)c(Cl)c1
Structure:
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