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Reaction Details
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TargetATP Phosphoribosyltransferase
LigandBDBM25321
Substrate/CompetitorBDBM25315
Meas. Tech.Enzyme Inhibition Assay
pH8.5±n/a
Temperature295.15±n/a K
Comments20% inhibition @ 10 uM.
Citation Cho, YIoerger, TRSacchettini, JC Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem51:5984-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
ATP Phosphoribosyltransferase
Name:ATP Phosphoribosyltransferase
Synonyms:ATP-PRT | ATP-PRTase | hisG
Type:Glycosyltransferase
Mol. Mass.:30473.85
Organism:Mycobacterium tuberculosis
Description:n/a
Residue:284
Sequence:
MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSG
ELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLV
RKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAV
LIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA
PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
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BDBM25321
NameBDBM25321
Synonyms:(4E)-4-[(4-chlorophenyl)(hydroxy)methylidene]-1-(pyridin-3-ylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione | ChemBridge pyrrolidine-2,3-dione, 1
TypeSmall organic molecule
Emp. Form.C26H23ClN2O6
Mol. Mass.494.924
SMILESCOc1cc(cc(OC)c1OC)C1C(C(=O)c2ccc(Cl)cc2)C(=O)C(=O)N1Cc1cccnc1
Structure
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BDBM25315
NameBDBM25315
Synonyms:Phosphoribosyl Pyrophosphate (PRPP) | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}oxolan-2-yl]methoxy}phosphonic acid
Type Pentosephosphate
Emp. Form.C5H13O14P3
Mol. Mass.390.0696
SMILESO[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O |r|
Structure
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