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Target
Mitogen-activated protein kinase 1
Ligand
BDBM365065
Substrate
n/a
Meas. Tech.
ERK-2 Enzymatic Assay
IC50
0.390±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US10278975 Publication Date 5/7/2019 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM365065
Synonyms:
(R)-9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)pyridin- 4-yl)-8,9-dihydro- 1,2,2a1,6,8- pentaazabenzo[cd]azulen- 7(6H)-one | US10278975, Compound I-26 | US10517878, Compound I-26 | US10842799, I-26 | US11376260, Example I-26 | US9867833, Compound I-26
Type:
Small organic molecule
Emp. Form.:
C26H25N9O2
Mol. Mass.:
495.5358
SMILES:
COc1ccc(C[C@H]2NC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1 |r|
Structure:
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