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Target
Proto-oncogene Wnt-1
Ligand
BDBM383990
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
IC50
2580±n/a nM
Citation
 KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof US Patent  US10280166 Publication Date 5/7/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM383990
Synonyms:
US10280166, Compound 181
Type:
Small organic molecule
Emp. Form.:
C28H28F2N8
Mol. Mass.:
514.5723
SMILES:
FC1(F)CCN(Cc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(ccnc5[nH]4)N4CCCCC4)c3c2)C1
Structure:
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