Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Ligand
BDBM384197
Substrate
n/a
Meas. Tech.
PTPN11 Enzymatic Assay
IC50
1941±n/a nM
Citation
 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA Heterocyclic inhibitors of PTPN11 US Patent  US10280171 Publication Date 5/7/2019 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Synonyms:
PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68019.14
Organism:
Homo sapiens (Human)
Description:
Q06124[E76K]
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM384197
Synonyms:
4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol | US10280171, Example 117 | US10851110, Example 117 | US11466017, Example 117
Type:
Small organic molecule
Emp. Form.:
C16H18ClN7O
Mol. Mass.:
359.813
SMILES:
CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl
Structure:
Search PDB for entries with ligand similarity: