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Target
Calpain-2 catalytic subunit
Ligand
BDBM25889
Substrate
BODIPY FL casein
Meas. Tech.
BODIPY Fluorescent Microplate Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
100±n/a nM
Citation
 Jones, MA; Morton, JD; Coxon, JM; McNabb, SB; Lee, HY; Aitken, SG; Mehrtens, JM; Robertson, LJ; Neffe, AT; Miyamoto, S; Bickerstaffe, R; Gately, K; Wood, JM; Abell, AD Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem 16:6911-23 (2008) [PubMed]  Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
Calpain II 80 kDa subunit | Calpain-2 | o-CAPN2
Type:
Enzyme
Mol. Mass.:
79914.19
Organism:
Ovis aries (sheep)
Description:
A8IF71
Residue:
700
Sequence:
MAGIAAKLAKDREAAEGLGSHERAVKYLNQDYAALRDECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICDDPQFITGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKAPPNLFRIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESRGSLQKLIRIRNPWGEVEWTGQWNDNCPNWNTVDPEVRESLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEEFTGQTNIHLSKKFFLTTRARERSDTFINLREVLNRFKLPPGEYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEANLEEIDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEAAGFKMPCQLHQVIVARFADDDLIIDFDNFVRCLIRLETLFRIFKQLDPENTGMIQLDLISWLCFSVL
  
Inhibitor
Name:
BDBM25889
Synonyms:
(2S)-2-[(5-formylfuran-2-yl)formamido]-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]butanamide | N-heterocyclic dipeptide aldehyde, 7
Type:
Small organic molecule
Emp. Form.:
C17H24N2O5
Mol. Mass.:
336.3829
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C=O)o1)C(C)C)C=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BODIPY FL casein
Synonyms:
4,4-difluoro-5,7-dimethyl-4-bora-3a,4adiaza-s-indacene-3-propionic acid (BODIPY-FL) labeled casein
Type:
fluorescent dye-labeled substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA