Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431085
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
19.0±n/a nM
Citation
Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinone compounds and their use as DAAO inhibitors US Patent US9931340 Publication Date 4/3/2018
More Info.:
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Inhibitor
Name:
BDBM50431085
Synonyms:
CHEMBL2338801 | US10202399, Example 12 | US10463663, Example 36 | US11129828, Example 36 | US9212147, 12 | US9290456, 36 | US9931340, Example 36
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2O2
Mol. Mass.:
284.2338
SMILES:
Oc1cc(CCc2ccc(cc2)C(F)(F)F)n[nH]c1=O