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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50242729
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
303±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50242729
Synonyms:
CHEMBL4090409 | US9932350, 2-4
Type:
Small organic molecule
Emp. Form.:
C16H20F2N4
Mol. Mass.:
306.3536
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2cc(F)c(F)cc12 |r,wU:6.9,wD:3.2,(67.11,-17.99,;65.78,-17.22,;65.77,-15.68,;64.44,-17.99,;63.11,-17.22,;61.77,-18,;61.78,-19.53,;63.12,-20.3,;64.44,-19.53,;60.45,-20.31,;60.46,-21.85,;61.8,-22.6,;61.81,-24.15,;60.47,-24.93,;59.14,-24.16,;57.81,-24.94,;56.47,-24.17,;55.14,-24.94,;56.47,-22.62,;55.14,-21.86,;57.8,-21.85,;59.14,-22.62,)|
Structure:
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