Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384560
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
58.0±n/a nM
Citation
 Altman, MDBrubaker, JDChilders, MLDonofrio, AFischmann, TGibeau, CRKattar, SDLesburg, CALim, JMaclean, JKMansoor, UFNorthrup, ABSanders, JMSmith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384560
Synonyms:
7-fluoro-6-methoxy-N- [trans-4-(morpholin-4- yl)cyclohexyl]quinazolin- 4-amine | US9932350, 2-12
Type:
Small organic molecule
Emp. Form.:
C19H25FN4O2
Mol. Mass.:
360.4258
SMILES:
COc1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F |r,wU:7.6,wD:10.13,(-.38,6.65,;-1.92,6.65,;-2.69,5.32,;-1.92,3.99,;-2.69,2.65,;-1.92,1.32,;-.38,1.32,;.39,-.01,;1.93,-.01,;2.7,-1.35,;1.93,-2.68,;.39,-2.68,;-.38,-1.35,;2.7,-4.02,;1.93,-5.35,;2.72,-6.65,;4.24,-6.65,;5,-5.33,;4.24,-4.02,;-2.69,-.01,;-4.23,-.01,;-5,1.32,;-4.23,2.65,;-5,3.99,;-4.23,5.32,;-5,6.65,)|
Structure:
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